-한국식품과학회지
김치에서 분리한 Lactobacillus plantarum CIB 001 급여가 고콜레스테롤혈증 흰쥐의 지질대사에 미치는 영향(Effects of Lactobacillus plantarum CIB 001 on lipid metabolism of hypercholesterolemic rats)
1Sang Do Cha, Ji Won Yu, 2Tae Woon Kim, 3Ho Seong Cho and 1Dong Hee Lee*
Abstract
The aim of the present study was to assese the anti-hypercholesterolemic effect of bile salt hydrolase-producing Lactobacillus plantarum CIB 001(KCTC 11717bp) in rats fed a high-cholesterol diet. Four treatment groups of rats(n=5) were fed experimental diets: normal diet(ND), ND plus L. plantarum CIB 001(NDL) at 5.0∼7.5 x 109 colony-forming unit(CFU)/day, high-cholesterol diet(HCD), HCD plus L. plantarum CIB 001(HCDL) at 5.0∼7.5 x 109 CFU/day for 6 weeks. Compared with HCD group, HCDL resulted in decreases in the serum triglyceride(P<0.05), total cholesterol(P<0.05) and the corresponding HDL-cholesterol concentration increased at the rate of 40%(P<0.05). HCDL group also induced a decrease in liver inflammation and steatosis. The present results suggest that supplementation of L. plantarum CIB 001 can have short-term(6 weeks) effects on the blood lipids and liver injury, as well as on atherogenic index and cardiac risk factor.